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Case Series
Case of primary thyroid rhabdomyosarcoma in children with literature review
1 Division of Oncology, Head and Neck Surgery, Department Surgery, Hasan Sadikin General Hospital/Universitas Padjadjaran, Bandung, Indonesia
2 Department of Pathology Anatomy, Hasan Sadikin General Hospital Bandung/Universitas Padjadjaran, Bandung, Indonesia
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Yohana Azhar
Division of Oncology, Head and Neck Surgery, Department Surgery, Hasan Sadikin General Hospital/Universitas Padjadjaran, Jl Pasteur No. 38, Bandung, West Jawa,
Indonesia
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Article ID: 100076Z12YA2020
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How to cite this article
Azhar Y, Agustina H. Case of primary thyroid rhabdomyosarcoma in children with literature review. J Case Rep Images Surg 2020;6:100076Z12YA2020.ABSTRACT
Primary thyroid embryonal rhabdomyosarcoma (ERMS) is an extremely rare tumor. Diagnostic and management of these cases can be challenging. This report presents cases of 7- and 8-year-old girls with non-orbital of non-parameningeal rhabdomyosarcoma (RMS), which is a new, seldom-reported variant of RMS in the head-neck region. These pediatric patients suffer from large swelling in the anterior neck that clinically resembles a thyroid mass. In the anterior neck, the entire thyroid lobe is replaced by a heterogeneous mass as shown from the results of a computed tomography (CT) scan. Usually, fine-needle aspiration cytology is non-diagnostically mistaken with an undifferentiated thyroid cancer. Total thyroidectomy with neck dissection in one patient was done and final histopathological results turn out to be ERMS; the diagnosis was confirmed by positive reactions to MyoD1 and myogenin. The children were subsequently treated with chemotherapy. Despite the rarity of these conditions, they remain an important part of the differential diagnosis for any thyroid nodule. Awareness of their presentation, work-up, and management is critical for oncologist and head and neck surgeons.
Keywords: Children, Primary rhabdomyosarcoma, Thyroid
SUPPORTING INFORMATION
Author Contributions
Yohana Azhar - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hasrayati Agustina - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Drafting the article, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Yohana Azhar et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
