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Case Report
Perianal Paget’s disease regression after treatment for triple negative breast cancer: A case report
1 Resident Medical Officer, Junior Medical Officer Unit, Hunter New England Local Health District, Waratah, NSW, Australia
2 Staff Specialist Pathologist, NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia
3 Consultant General and Breast Surgeon, General Surgery, Calvary Mater Newcastle, Waratah, NSW, Australia
Address correspondence to:
Carissa Vici
Hunter New England JMO Network, Cnr Turton and Tinonee Roads, Waratah, NSW 2298,
Australia
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Article ID: 100130Z12CV2024
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Vici C, Vilain R, Velaiutham S. Perianal Paget’s disease regression after treatment for triple negative breast cancer: A case report. J Case Rep Images Surg 2024;10(1):10–14.ABSTRACT
Introduction: Extramammary Paget’s disease (EMPD) is a disease affecting apocrine gland-bearing tissue found in the anogenital region, axilla, and other sites. Due to the rarity of this disease, the etiology and pathogenesis are poorly understood. Extramammary Paget’s disease is classified into primary and secondary disease, with secondary EMPD almost always associated with synchronous or metachronous malignancy. The management of secondary perianal EMPD is surgical excision of the area with consideration of radiotherapy and topical or systemic chemotherapy in addition to treating the underlying malignancy.
Case Report: This report describes a patient with partially resected perianal Paget’s disease following an abdominoperineal resection of anal carcinoma. The patient then needed treatment for a metachronous invasive triple-negative breast cancer. Following breast cancer treatment, the perianal Paget’s disease appeared to have regressed.
Conclusion: We report a rare case of perianal extramammary Paget’s disease with metachronous colorectal, then breast cancer responding to treatment with systemic chemotherapy for triple-negative breast cancer.
Keywords: Extramammary Paget’s disease, Perianal Paget’s disease, Spontaneous regression, Triple negative breast cancer
SUPPORTING INFORMATION
Author Contributions
Carissa Vici - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ricardo Vilain - Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Shanta Velaiutham - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Carissa Vici et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
